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Live Better Science · Personal Scientific Evidence System
What is the strongest published evidence that low-dose mTOR inhibition or epigenetic reprogramming improves human longevity outcomes?
[KAREN-EDITED] Real human evidence for partial reprogramming is limited to animal models.
Epigenetic reprogramming using the Yamanaka factors (OSK) has been shown to restore youthful DNA methylation patterns, transcript profiles, and tissue function in animal models without erasing cellular identity [papers/PMID:37437248.txt]. Another study found that increased hyaluronan levels in transgenic mice improved healthspan and extended lifespan [papers/PMID:37612507.txt]. However, human evidence for the effectiveness of epigenetic reprogramming in improving longevity outcomes is currently limited.
Caveats
- Only mouse models reported
- Conflicts of interest disclosed
- No human RCT yet
Citations
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primary
papers/PMID:37437248.txt
To provide evidence for epigenetic reprogramming in reversing cellular aging
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supporting
papers/PMID:37612507.txt
To provide additional evidence for the potential benefits of epigenetic reprogramming
- Source
- papers/PMID:37437248.txt and papers/PMID:37612507.txt
- Published#
- N/A
- Your body
- N/A
- Compute
- N/A
- Caveats
- Animal models, conflict of interest